anti- RSPO2 antibody

anti- RSPO2 antibody

Product Name

RSPO2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

IMMUNOGEN INFORMATION

Immunogen

R-spondin 2 homolog

Synonyms

CRISTIN2, hRspo2, R spondin 2, Roof plate specific spondin 2, RSPO2

Observed MW

33 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:3000; IP: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

Q6UXX9

IMAGES