anti- RYK antibody

anti- RYK antibody

Product Name

RYK antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

IMMUNOGEN INFORMATION

Immunogen

RYK receptor-like tyrosine kinase

Synonyms

JTK5, JTK5A, RYK, RYK1, Tyrosine protein kinase RYK

Observed MW

68 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P34925

IMAGES

Immunohistochemistry of paraffin-embedded human kidney using FNab07548(RYK antibody) at dilution of 1:50

Immunofluorescent analysis of SH-SY5Y cells using FNab07548 ( RYK Antibody) at dilution of 1:50 and Alexa Fluor488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07548(RYK antibody) at dilution of 1:1000