anti- SAFB antibody

anti- SAFB antibody

Product Name

SAFB antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Binds to scaffold/matrix attachment region(S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex(consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing(By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter(By similarity). Can inhibit cell proliferation.

IMMUNOGEN INFORMATION

Immunogen

scaffold attachment factor B

Synonyms

HAP, HET, SAFB1

Observed MW

150 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15424

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab07578(SAFB Antibody) at dilution of 1:50

MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab07578(SAFB Antibody) at dilution of 1:1000