anti- SH3BP4 antibody

anti- SH3BP4 antibody

Product Name

SH3BP4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

IMMUNOGEN INFORMATION

Immunogen

SH3-domain binding protein 4

Synonyms

BOG25, EHB10, TTP

Observed MW

120 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9P0V3

IMAGES

IP Result of anti-SH3BP4 (IP:FNab07830, 4ug; Detection:FNab07830 1:300) with mouse lung tissue lysate 3600ug.

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab07830(SH3BP4 antibody) at dilution of 1:300