anti- SH3PXD2A antibody

anti- SH3PXD2A antibody

Product Name

SH3PXD2A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases(ADAMs), NADPH oxidases(NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1-or NOX3-dependent reactive oxygen species(ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

IMMUNOGEN INFORMATION

Immunogen

SH3 and PX domains 2A

Synonyms

FISH, KIAA0418, SH3MD1, TKS5

Observed MW

140 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q5TCZ1

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer using FNab07836(SH3PXD2A antibody) at dilution of 1:50

Immunofluorescent analysis of HepG2 cells using FNab07836 (SH3PXD2A antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG

HeLa cells were subjected to SDS PAGE followed by western blot with FNab07836(SH3PXD2A antibody) at dilution of 1:500