anti- SIGMAR1 antibody

anti- SIGMAR1 antibody

Product Name

SIGMAR1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration(PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria(By similarity).

IMMUNOGEN INFORMATION

Immunogen

sigma non-opioid intracellular receptor 1

Synonyms

FLJ25585, hSigmaR1, OPRS1, SIG 1R, Sigma 1 type opioid receptor, Sigma1 receptor, Sigma1R, SIGMAR1, SR BP, SR BP1, SR31747 binding protein, SRBP

Observed MW

27 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q99720

IMAGES

Immunohistochemistry of paraffin-embedded human liver cancer using FNab07864(SIGMAR1 antibody) at dilution of 1:50

mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab07864(SIGMAR1 antibody) at dilution of 1:500