anti- SKAP2 antibody

anti- SKAP2 antibody

Product Name

SKAP2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

IMMUNOGEN INFORMATION

Immunogen

src kinase associated phosphoprotein 2

Synonyms

PRAP, RA70, SAPS, SCAP2, SKAP55R

Observed MW

50 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

O75563

IMAGES

Immunohistochemistry of paraffin-embedded mouse stomach using FNab07890( SKAP2 Antibody) at dilution of 1:50

human liver tissue were subjected to SDS PAGE followed by western blot with FNab07890(SKAP2 antibody) at dilution of 1:1500