anti- SLC12A5-Specific antibody

anti- SLC12A5-Specific antibody

Product Name

SLC12A5-Specific antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl-cotransporter that is essential for Cl-homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.

IMMUNOGEN INFORMATION

Immunogen

solute carrier family 12(potassium-chloride transporter), member 5

Synonyms

hKCC2, K Cl cotransporter 2, KCC2, KIAA1176, Neuronal K Cl cotransporter, SLC12A5

Observed MW

126 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9H2X9

IMAGES

Immunohistochemistry of paraffin-embedded human brain using FNab07908(SLC12A5-Specific antibody) at dilution of 1:100

human brain tissue were subjected to SDS PAGE followed by western blot with FNab07908(SLC12A5-Specific antibody) at dilution of 1:300