anti- SOST antibody

anti- SOST antibody

Product Name

SOST antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

IMMUNOGEN INFORMATION

Immunogen

sclerosteosis

Synonyms

sclerosteosis, Sclerostin, SOST, VBCH

Observed MW

30 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

Q9BQB4

IMAGES

Immunohistochemistry of paraffin-embedded human liver tissue slide using FNab08119( SOST Antibody) at dilution of 1:50

Hela cells were subjected to SDS PAGE followed by western blot with FNab08119( SOST Antibody) at dilution of 1:1000