anti- SRGAP2 antibody

anti- SRGAP2 antibody

Product Name

SRGAP2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

IMMUNOGEN INFORMATION

Immunogen

SLIT-ROBO Rho GTPase activating protein 2

Synonyms

ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3

Observed MW

120-140 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O75044

IMAGES

Immunohistochemistry of paraffin-embedded human kidney slide using FNab08225(SRGAP2 Antibody) at dilution of 1:50

Various lysates were subjected to SDS PAGE followed by western blot with FNab08225(SRGAP2 antibody) at dilution of 1:1000