anti- STK36 antibody

anti- STK36 antibody

Product Name

STK36 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Serine/threonine protein kinase which plays an important role in the sonic hedgehog(Shh) pathway by regulating the activity of GLI transcription factors(PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization(PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur(PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function(By similarity). Essential for construction of the central pair apparatus of motile cilia.

IMMUNOGEN INFORMATION

Immunogen

serine/threonine kinase 36, fused homolog(Drosophila)

Synonyms

KIAA1278

Observed MW

144 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NRP7

IMAGES

Immunohistochemistry of paraffin-embedded human prostate using FNab08335(STK36 antibody) at dilution of 1:50

IP Result of anti-STK36 (IP:FNab08335, 4ug; Detection:FNab08335 1:500) with mouse testis tissue lysate 4000ug.

mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab08335(STK36 antibody) at dilution of 1:300