anti- TELO2 antibody

anti- TELO2 antibody

Product Name

TELO2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.

IMMUNOGEN INFORMATION

Immunogen

TEL2, telomere maintenance 2, homolog

Synonyms

KIAA0683

Observed MW

92 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IF

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9Y4R8

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