anti- TFE3 antibody

anti- TFE3 antibody

Product Name

TFE3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription factor that specifically recognizes and binds E-box sequences(5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

IMMUNOGEN INFORMATION

Immunogen

transcription factor binding to IGHM enhancer 3

Synonyms

bHLHe33, RCCP2, TFE3, TFEA, Transcription factor E3

Observed MW

65KD

APPLICATION

Tested Application

ELISA, WB, IP,IHC

Recommended Dilution

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P19532

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