anti- TRPM5 antibody

anti- TRPM5 antibody

Product Name

TRPM5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Voltage-modulated Ca(2+)-activated, monovalent cation channel(VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

IMMUNOGEN INFORMATION

Immunogen

transient receptor potential cation channel, subfamily M, member 5

Synonyms

LTrpC 5, LTRPC5, MTR1, TRPM5

Observed MW

98 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:500-1:5000; IP: 1:200-1:1000; IF: N/A

UNIPROT INFORMATION

UniProt ID

Q9NZQ8

IMAGES