anti- UBASH3A-Specific antibody

anti- UBASH3A-Specific antibody

Product Name

UBASH3A-Specific antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

UBASH3A gene encodes ubiquitin-associated and SH3 domain-containing protein A(UBASH3A) also known as T-cell ubiquitin ligand 1(TULA1) which is one of two family members belonging to the T-cell ubiquitin ligand(TULA) family. UBASH3A gene expression is limited to only a few tissues, with its highest expression in spleen, peripheral blood leukocytes, and bone marrow. UBASH3A protein is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases oth family members can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells via its interaction with apoptosis-inducing factor(AIF). This antibody is UBASH3A-specific.

IMMUNOGEN INFORMATION

Immunogen

ubiquitin associated and SH3 domain containing, A

Synonyms

Cbl interacting protein 4, CLIP4, STS 2, STS2, T cell ubiquitin ligand, TULA, UBASH3A

Observed MW

69 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IP

Recommended Dilution

WB: 1:200-1:2000; IF: 1:10-1:100；IP: 1:200-1:2000