anti- uPAR antibody

anti- uPAR antibody

Product Name

uPAR antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559)

IMMUNOGEN INFORMATION

Immunogen

plasminogen activator, urokinase receptor

Synonyms

CD87, MO3, PLAUR, U PAR, UPAR, URKR

Observed MW

37-70 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:200-1:2000; IP: 1:200-1:1000

UNIPROT INFORMATION

UniProt ID

Q03405

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