anti- USP14 antibody

anti- USP14 antibody

Product Name

USP14 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation(ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions(NMJs).

IMMUNOGEN INFORMATION

Immunogen

ubiquitin specific peptidase 14(tRNA-guanine transglycosylase)

Synonyms

Deubiquitinating enzyme 14, TGT, Ubiquitin thiolesterase 14, USP14

Observed MW

52-60 kDa

APPLICATION

Tested Application

ELISA, WB, IF, FC

Recommended Dilution

WB: 1:500-1:5000; IP: 1:500-1:5000; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P54578

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