anti- LOXL1 antibody

anti- LOXL1 antibody

Product Name

LOXL1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.

IMMUNOGEN INFORMATION

Immunogen

lysyl oxidase-like 1

Synonyms

LOL, LOXL, LOXL1, Lysyl oxidase homolog 1, lysyl oxidase like 1, Lysyl oxidase like protein 1

Observed MW

70kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500 - 1:2000

UNIPROT INFORMATION

UniProt ID

Q08397

IMAGES

A549 cells were subjected to SDS PAGE followed by western blot with FNab09975(LOXL1 Antibody) at dilution of 1:1000