anti- MAP2K4 antibody

anti- MAP2K4 antibody

Product Name

MAP2K4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

MAP2K4

Synonyms

JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1

Observed MW

44 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:100

UNIPROT INFORMATION

UniProt ID

P45985

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer using FNab10073( MAP2K4 Antibody) at dilution of 1:100

Immunofluorescent analysis of Hela cells using MAP2K4 antibody(FNab10073) at 1:50 dilution.

Mcf-7 cells were subjected to SDS PAGE followed by western blot with FNab10073(MAP2K4 antibody) at dilution of 1:1000