anti- ARHGEF1 antibody

Embark on a journey into the intricate world of Rho guanine nucleotide exchange factors (ARHGEFs) with our Anti-ARHGEF1 Polyclonal Antibody, available in a convenient 100µg size. ARHGEF1, also known as p115-RhoGEF, is a vital regulator of Rho family GTPases, influencing cytoskeletal dynamics, cell migration, and adhesion.

This polyclonal antibody, raised in rabbits, offers exceptional sensitivity and specificity, ensuring accurate and reproducible results in various applications, from Western blotting to immunofluorescence. Whether you're investigating ARHGEF1's functions in cell motility, its role in neuronal development, or its implications in cancer progression, our antibody is your trusted research companion.

The 100µg size provides cost-effective versatility, catering to both small-scale experiments and larger research initiatives. Its consistent quality and purity make it an ideal choice for researchers across diverse disciplines, from cell biology to neuroscience.

Choose our Anti-ARHGEF1 Polyclonal Antibody to propel your research forward and gain fresh insights into the complex world of Rho GTPase regulation. Count on its performance, specificity, and reliability to drive your scientific discovery forward and contribute to the body of knowledge in your field.

Product Name

ARHGEF1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

IMMUNOGEN INFORMATION

Immunogen

Rho guanine nucleotide exchange factor(GEF) 1

Synonyms

ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5, ARHG1

Observed MW

102-110 kDa

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q92888

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