anti- PTP1B antibody

Enhance your studies of protein tyrosine phosphatase 1B (PTP1B) with our Anti-PTP1B Antibody, available in a 100µg size. PTP1B plays a crucial role in regulating insulin signaling and cell growth, making this antibody an essential tool for your research endeavors. Here are the key features: PTP1B Antibody Highlights: Target-Specific Precision: This antibody is rigorously validated to specifically recognize PTP1B, ensuring accurate and reliable results in your studies of insulin signaling, metabolism, and cell proliferation. Versatile Applications: Compatible with various research techniques, including Western blotting, immunoprecipitation, and immunohistochemistry. It's an ideal choice for researchers investigating diabetes, metabolic disorders, and cell signaling pathways. High Sensitivity: The Anti-PTP1B Antibody is optimized for sensitivity, allowing you to detect low-abundance PTP1B in complex biological samples, helping you uncover subtle changes in PTP1B expression. Broad Research Impact: From understanding insulin resistance to investigating metabolic disorders, this antibody is a valuable tool for researchers exploring the regulatory mechanisms of cell growth and metabolism. Incorporate the Anti-PTP1B Antibody into your research to deepen your understanding of PTP1B's role in cellular processes, particularly in diabetes, metabolism, and growth control. Its specificity and reliability make it an invaluable asset for scientists and researchers in diverse fields.

Product Name

PTP1B antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

IMMUNOGEN INFORMATION

Immunogen

protein tyrosine phosphatase, non-receptor type 1

Synonyms

PTP 1B, PTP1B, PTPN1

Observed MW

50 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P18031

IMAGES