anti- PTEN antibody

Our Anti-PTEN Antibody is your essential tool for exploring the functions of Phosphatase and Tensin Homolog (PTEN), a crucial player in regulating cell growth and preventing abnormal cell division. With a 100µg size, this antibody provides the specificity and sensitivity you need for accurate protein detection. Key Features: Precise Targeting: This antibody is rigorously validated to specifically recognize PTEN, ensuring reliable results in your research on cell signaling, cancer biology, and growth control. Versatile Applications: Compatible with a variety of research techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It's ideal for researchers studying cancer, cell biology, and signal transduction pathways. Enhanced Sensitivity: The Anti-PTEN Antibody is optimized for high sensitivity, allowing you to detect low-abundance PTEN in complex biological samples, helping you uncover subtle changes in PTEN expression. Broad Research Impact: From unraveling the mechanisms of tumorigenesis to investigating cell proliferation, this antibody is a valuable asset for researchers exploring cell growth regulation and its implications in disease. Incorporate the Anti-PTEN Antibody into your research to deepen your understanding of PTEN's role in cellular processes, particularly in cancer and growth control. Its precision and reliability make it an invaluable tool for scientists and researchers in diverse fields.

Product Name

PTEN antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

IMMUNOGEN INFORMATION

Immunogen

phosphatase and tensin homolog

Synonyms

MMAC1, TEP1

Observed MW

55 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500 - 1:2000

UNIPROT INFORMATION

UniProt ID

P60484

IMAGES