anti- SMN antibody

anti- SMN antibody

Product Name

SMN antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The survival of motor neurons(SMN) genes are the disease genes of spinal muscular atrophy(SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody can recognize human,mouse and rat SMN.

IMMUNOGEN INFORMATION

Immunogen

survival of motor neuron 2, centromeric

Synonyms

C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1,SMN, SMN2, SMNC, SMNT, Survival motor neuron protein

Observed MW

38kd

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:1000-1:6000; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q16637

IMAGES

Immunofluorescent analysis of ( -20℃ Ethanol) fixed HEK-293 cells using FNab08033 (SMN antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated Goat Anti-Mouse IgG(H+L)

A375 cells were subjected to SDS PAGE followed by western blot with FNab08033(SMN antibody) at dilution of 1:3000