anti- SNAPIN antibody

anti- SNAPIN antibody

Product Name

SNAPIN antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor(PubMed:25898167).

IMMUNOGEN INFORMATION

Immunogen

SNAP-associated protein

Synonyms

BLOC1S7, SNAP25BP, SNAPAP

Observed MW

15-18 kDa

APPLICATION

Tested Application

ELISA, IF, WB, IHC, FC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O95295

IMAGES

Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08060(SNAPIN Antibody) at dilution of 1:200

IP Result of anti-SNAPIN (IP:FNab08060, 5ug; Detection:FNab08060 1:300) with mouse brain tissue lysate 4000ug.

rat brain tissue were subjected to SDS PAGE followed by western blot with FNab08060(SNAPIN Antibody) at dilution of 1:200