anti- SNX17 antibody

anti- SNX17 antibody

Product Name

SNX17 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate(PtdIns(3P)).

IMMUNOGEN INFORMATION

Immunogen

sorting nexin 17

Synonyms

KIAA0064

Observed MW

52 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15036

IMAGES

Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab08084(SNX17 Antibody) at dilution of 1:50

Immnuofluorescent analysis of HepG2 cells using FNab08084(SNX17 Antibody) at dilution of 1:50

IP Result of anti-SNX17 (IP:FNab08084, 4ug; Detection:FNab08084 1:1000) with HeLa cells lysate 1200ug.

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab08084(SNX17 antibody) at dilution of 1:500