anti- SNX6 antibody

anti- SNX6 antibody

Product Name

SNX6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate(Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex(PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier(ETC)(Probable). Does not have in vitro vesicle-to-membrane remodeling activity(PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R(PubMed:17148574). May function as link between transport vesicles and dynactin(Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network(PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation(PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B(By similarity). May contribute to transcription regulation(Probable).

IMMUNOGEN INFORMATION

Immunogen

sorting nexin 6

Observed MW

47 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9UNH7

IMAGES

Immunohistochemistry of paraffin-embedded human heart slide using FNab08095(SNX6 Antibody) at dilution of 1:50

RAW 264.7 cells were subjected to SDS PAGE followed by western blot with FNab08095(SNX6 Antibody) at dilution of 1:600