anti- STAT3 antibody

anti- STAT3 antibody

Product Name

STAT3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene(PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6(IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1(PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation(By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.

IMMUNOGEN INFORMATION

Immunogen

signal transducer and activator of transcription 3(acute-phase response factor)

Synonyms

Acute phase response factor, APRF, HIES, STAT3

Observed MW

88 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:1000-1:4000; IP: 1:1000-1:4000; IHC: 1:50-1:500; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P40763

IMAGES

Immunohistochemistry of paraffin-embedded human cervical cancer using FNab08299(STAT3 antibody) at dilution of 1:100

IP Result of anti-STAT3 (IP: FNab08299, 3ug; Detection: FNab08299 1:2000) with HeLa cells lysate 3000ug.

K-562 cells were subjected to SDS PAGE followed by western blot with FNab08299(STAT3 antibody) at dilution of 1:500