anti- STIM1 antibody

anti- STIM1 antibody

Product Name

STIM1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores(By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+)(CRAC) channel subunit ORAI1(PubMed:16208375). Involved in enamel formation(By similarity). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch(By similarity).

IMMUNOGEN INFORMATION

Immunogen

stromal interaction molecule 1

Synonyms

D11S4896E, GOK, STIM1, stromal interaction molecule 1

Observed MW

77kd

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000

IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q13586

IMAGES

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab08321(STIM1 Antibody) at dilution of 1:200(under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08321(STIM1 Antibody) at dilution of 1:500