anti- STIM2 antibody

anti- STIM2 antibody

Product Name

STIM2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+)(CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

IMMUNOGEN INFORMATION

Immunogen

stromal interaction molecule 2

Synonyms

KIAA1482

Observed MW

85-115 kDa

APPLICATION

Tested Application

ELISA, IHC, IP, WB

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9P246

IMAGES

Immunohistochemistry of paraffin-embedded human spleen tissue slide using FNab08322(STIM2 Antibody) at dilution of 1:200

IP Result of anti-STIM2 (IP:FNab08322, 3ug; Detection:FNab08322 1:500) with HEK-293 cells lysate 2000ug.

HeLa cells were subjected to SDS PAGE followed by western blot with FNab08322(STIM2 Antibody) at dilution of 1:1000