FineTest
SKU:FNab08572
anti- TDP1 antibody
anti- TDP1 antibody
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Product Name
TDP1 antibodSize
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
IMMUNOGEN INFORMATION
Immunogen
tyrosyl-DNA phosphodiesterase 1
Observed MW
68 kDa
APPLICATION
Tested Application
ELISA, WB, IP
Recommended Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
UNIPROT INFORMATION
UniProt ID
IMAGES
- Product Name
- TDP1 antibody
- Catalogue No.
- FNab08572
- Size
- 100µg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Host
- Rabbit
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
- Immunogen
- tyrosyl-DNA phosphodiesterase 1
- Observed MW
- 68 kDa
- Tested Application
- ELISA, WB, IP
- Recommended Dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000
- UniProt ID
- Q9NUW8
-
IP Result of anti-TDP1 (IP:FNab08572, 4ug; Detection:FNab08572 1:1000) with HeLa cells lysate 1200ug. -
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab08572(TDP1 antibody) at dilution of 1:1000
