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Immunohistochemistry of paraffin-embedded human kidney using FNab09312(USP16 antibody) at dilution of 1:100 -
IP Result of anti-USP16 (IP:FNab09312, 5ug; Detection:FNab09312 1:1000) with HeLa cells lysate 880ug. -
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09312(USP16 antibody) at dilution of 1:1000
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FineTest
SKU:FNab09312
anti- USP16 antibody
anti- USP16 antibody
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Product Name
USP16 antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
Specifically deubiquitinates 'Lys-120' of histone H2A(H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3(H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B-and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
IMMUNOGEN INFORMATION
Immunogen
ubiquitin specific peptidase 16
Synonyms
Deubiquitinating enzyme 16, Ubiquitin thiolesterase 16, UBP M, USP16
Observed MW
94 kDa
APPLICATION
Tested Application
ELISA, WB, IHC, IP
Recommended Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200
UNIPROT INFORMATION
UniProt ID
IMAGES
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