anti- VMAT2 antibody

Product Name

VMAT2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

VMAT2 is a vesicular monoamine transporter that is responsible for the uptake and storage of monoamines(dopaine, norepinephrine, epinephrine, histamine and serotonin) in neurons, endocrine cells, and tumors deriving from these cells. Histamine-producing endocrine tumors(gastric carcinoids) expressed VMAT2 almost exclusively, thus VMAT2 is useful in classification of neuroendocrine tumors. Reduced expression of VMAT2 has often been observed in Parkinson’s diseased(PD) brain, and detection of VMAT2 can be used to reflect the dopamine neuron loss and predict the disease process. VMAT2 migrated as a major band of 65-75 kDa and a minor band of 55-60 kDa, representing the glycosylated form and native form.

IMMUNOGEN INFORMATION

Immunogen

solute carrier family 18(vesicular monoamine), member 2

Synonyms

Monoamine transporter, SLC18A2, SVAT, SVMT, VAT2, Vesicular amine transporter 2, VMAT2

Observed MW

56 kDa, 66 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

Q05940

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