anti- YWHAB antibody

PRODUCT INFORMATION

Product Name

YWHAB antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form(by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activatation of MAP kinases via AKAP13.

IMMUNOGEN INFORMATION

Immunogen

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Synonyms

14 3 3, 14 3 3 alpha, 14 3 3 protein beta/alpha, YWHAB

Observed MW

28 kDa

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P31946

Immunohistochemical of paraffin-embedded human colon cancer using FNab09575(YWHAB antibody) at dilution of 1:50