anti- ZBTB38 antibody

Product Name

ZBTB38 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements(5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner(PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites(CFS) stability in a RBBP6-and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons(By similarity).

IMMUNOGEN INFORMATION

Immunogen

zinc finger and BTB domain containing 38

Synonyms

ZBTB38, FLJ31131, FLJ35036, CIBZ, FLJ22332

Observed MW

134 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q8NAP3

Immunohistochemistry of paraffin-embedded human testis using FNab09593(ZBTB38 antibody) at dilution of 1:50

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09593(ZBTB38 antibody) at dilution of 1:1000