anti- GAD1 antibody

Unlock the intricacies of brain function and neurotransmission with our Anti-GAD1 Antibody, available in a 100µg size. GAD1 (Glutamate Decarboxylase 1) is a pivotal enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), playing a crucial role in inhibitory neurotransmission. This antibody is meticulously designed to specifically target GAD1, enabling you to study its functions with precision.

Key Features:

• Exceptional Specificity: Thoroughly validated to exclusively bind to GAD1, minimizing the potential for cross-reactivity with other proteins.
• Versatile Applications: Ideal for various experimental techniques, including Western blotting, immunofluorescence, and immunoprecipitation, empowering your research in neurotransmission and brain function.
• Adequate Quantity: With 100µg of antibody, you have ample material for multiple experiments, reducing the need for frequent restocking.
• Quality Assurance: Manufactured under strict quality control measures to ensure the consistency and reliability of your results.
• Unveil Neurological Mechanisms: Whether you're investigating GAD1's role in neurodegenerative diseases, synaptic plasticity, or neurotransmitter balance, our Anti-GAD1 Antibody is your indispensable tool.

Product Name

GAD1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

IMMUNOGEN INFORMATION

Immunogen

glutamate decarboxylase 1

Synonyms

FLJ45882, GAD, GAD 67, GAD1, GAD67, Glutamate decarboxylase 1, SCP

Observed MW

67 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500 - 1:2000

UNIPROT INFORMATION

UniProt ID

Q99259

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