anti- beta-Catenin antibody

Unlock the mysteries of cellular signaling pathways with our Anti-beta-Catenin Antibody. This 100µg antibody is your gateway to investigating beta-catenin, a multifunctional protein that plays pivotal roles in cell adhesion, Wnt signaling, and embryonic development.

Precision-engineered for reliability, this antibody boasts exceptional specificity and sensitivity, ensuring precise results across various applications, including immunofluorescence, western blotting, and immunoprecipitation. Whether you're exploring cancer biology, tissue regeneration, or developmental biology, this antibody is an indispensable tool for your research.

Beta-catenin's versatile functions include its role as a key mediator of the canonical Wnt signaling pathway, where it regulates gene expression and influences cell fate decisions. Dysregulation of beta-catenin has profound implications in cancer and developmental disorders, making it a compelling target for research.

With our Anti-beta-Catenin Antibody, you can delve deep into the intricate world of cellular signaling pathways, potentially uncovering novel insights into disease mechanisms and therapeutic strategies.

Product Name

beta-Catenin antibody

Size

100µg

Form

liquid

Purification

protein A+G purified

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

catenin(cadherin-associated protein), beta 1, 88kDa

Synonyms

b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, β catenin, β-catenin

Observed MW

90 kDa

APPLICATION

Tested Application

ELISA, IF, WB, IHC, IP

Recommended Dilution

WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500

UNIPROT INFORMATION

UniProt ID

P35222

IMAGES