anti- CASP14 antibody

Our Anti-CASP14 Antibody, available in a 100µg vial, is a valuable research tool for scientists investigating the role of caspase-14 (CASP14) in epithelial differentiation and skin barrier function. CASP14 is a unique caspase predominantly expressed in the epidermis and involved in the proteolytic processing of epidermal structural proteins.

This antibody is meticulously designed to selectively recognize CASP14, ensuring accurate and reliable results in your experiments. It is compatible with various applications, including Western blotting and immunohistochemistry, providing versatility in your research.

With the 100µg vial size, you'll have an ample supply of this high-quality antibody for multiple experiments, ensuring cost-effectiveness and consistent results. Explore the intricate world of epidermal differentiation and skin biology with confidence, knowing you have a trusted research partner.

Product Name

CASP14 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

IMMUNOGEN INFORMATION

Immunogen

CASP14

Synonyms

CASP14, ARCI12, caspase-14

Observed MW

30 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:500 - 1:2000; IF: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P31944

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