anti- AGER antibody

Discover the future of advanced research in the realm of immunology and biology with our state-of-the-art Anti-AGER Antibody. This meticulously crafted antibody, available in a convenient 100µg size, is designed to meet the exacting demands of the scientific community.

The Anti-AGER Antibody offers unparalleled specificity and sensitivity, making it an indispensable tool for a wide array of applications. Researchers exploring the intricacies of the AGER (Advanced Glycation End-Product Receptor) will find this antibody to be an ideal choice, whether employed in Western blotting, immunohistochemistry, or other experimental avenues.

What truly distinguishes our Anti-AGER Antibody is its remarkable performance. Through rigorous testing and validation, we have ensured that this antibody consistently delivers reliable and reproducible results. By minimizing experimental variability, it streamlines your research, saving both time and resources.

Empower your research with the confidence that comes from using a high-quality, meticulously crafted Anti-AGER Antibody. Elevate your scientific pursuits and become a part of the transformative advancements in immunology and biology. Trust in our dedication to quality and innovation as you delve into the cutting-edge possibilities unlocked by the Anti-AGER Antibody.

Product Name

AGER antibody

Size

100µg

Form

liquid

Purification

protein A+G purified

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

IMMUNOGEN INFORMATION

Immunogen

advanced glycosylation end product-specific receptor

Synonyms

AGER, RAGE

Observed MW

43 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:1000-1:5000

UNIPROT INFORMATION

UniProt ID

Q15109

IMAGES