anti- Cdc20 antibody

Unravel the intricate mechanisms governing cell division with our Anti-Cdc20 Antibody, now available in a 100µg size. Cdc20, or cell division cycle 20, is a key regulatory protein essential for the transition from metaphase to anaphase during the cell cycle. It serves as an activator of the anaphase-promoting complex/cyclosome (APC/C), orchestrating the degradation of key cell cycle regulators and ensuring accurate chromosome segregation.

This monoclonal antibody offers high specificity and sensitivity, making it an indispensable tool for researchers investigating cell cycle regulation, mitosis, and the control of genomic stability. With 100µg of this antibody, you'll have a substantial supply for multiple experiments, ensuring the uninterrupted progression of your research.

Explore the intricate role of Cdc20 in the cell cycle, its interactions with APC/C, and its significance in maintaining chromosomal integrity. Investigate the molecular intricacies of Cdc20-mediated processes, contributing to our understanding of cell division control and its implications in cancer and developmental biology.

Product Name

Cdc20 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

IMMUNOGEN INFORMATION

Immunogen

cell division cycle 20 homolog

Synonyms

CDC20, CDC20A, p55CDC

Observed MW

55 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q12834

IMAGES

 

Immunohistochemistry of paraffin-embedded human colon cancer using FNab09997(CDC20 antibody) at dilution of 1:10

HeLa cells were subjected to SDS PAGE followed by western blot with FNab09997(CDC20 antibody) at dilution of 1:1000