anti- Caspase 1 antibody

Delve into the intricate world of inflammation and cell death regulation with our Anti-Caspase 1 Antibody, now available in a convenient 100µg size. Caspase 1, also known as interleukin-1β-converting enzyme (ICE), is a crucial player in the initiation of inflammatory responses by processing pro-inflammatory cytokines. This antibody offers the specificity and sensitivity needed for your research endeavors.

In addition to its role in inflammation, Caspase 1 is involved in pyroptosis, a highly inflammatory form of programmed cell death. With our 100µg antibody, you'll have a generous supply for your experiments, ensuring cost-effectiveness and consistent results.

Product Name

Caspase 1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.

IMMUNOGEN INFORMATION

Immunogen

caspase 1

Synonyms

CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45

Observed MW

45-47 kDa, 30 kDa, 35 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P29466

IMAGES

Immunohistochemistry of paraffin-embedded human stomach tissue slide using FNab10015(CASP1 Antibody) at dilution of 1:100

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab10015(CASP1 antibody) at dilution of 1:1000