anti- Caspase 8 antibody

Our Anti-Caspase 8 Antibody (100µg) is an essential tool for researchers investigating apoptosis and immune signaling pathways. Caspase 8, a pivotal initiator caspase, plays a central role in apoptosis triggered by death receptors. This antibody, designed to target Caspase 8, ensures precise and reliable results in your experiments.

With 100µg of this antibody per vial, you'll have an ample supply for multiple experiments, reducing the need for frequent reordering. Whether you're conducting Western blots, immunohistochemistry, or flow cytometry, this antibody consistently delivers high-quality performance.

Researchers can trust the specificity and sensitivity of this antibody, which is produced using advanced techniques and high-quality materials. Its reliability makes it an indispensable asset for projects aiming to elucidate the role of Caspase 8 in apoptosis and immune responses.

Advance your research on apoptosis and immune signaling with confidence using our Anti-Caspase 8 Antibody. By utilizing this antibody, you contribute to the progress of scientific knowledge in these critical fields.

Product Name

Caspase 8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.

IMMUNOGEN INFORMATION

Immunogen

caspase 8, apoptosis-related cysteine peptidase

Synonyms

Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5

Observed MW

53-57 kDa, 32-45 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q14790

IMAGES

Immunohistochemistry of paraffin-embedded mouse lung using FNab10024(CASP8 antibody) at dilution of 1:100

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab10024(CASP8 antibody) at dilution of 1:1000