anti- DDR1 antibody

The anti-DDR1 antibody, available in a 100µg size, is a valuable tool for researchers investigating the functions of Discoidin Domain Receptor 1 (DDR1) in cellular processes and signaling pathways. DDR1 is a receptor tyrosine kinase involved in cell adhesion and collagen binding, playing a critical role in various physiological and pathological processes.

This antibody is meticulously designed to specifically target DDR1 with exceptional specificity and sensitivity, making it ideal for various applications, including Western blotting, immunohistochemistry, and cell adhesion assays.

Our anti-DDR1 antibody is sourced from high-quality materials and undergoes rigorous validation to ensure reliable and reproducible results. It is a trusted choice for researchers studying receptor tyrosine kinases, cell adhesion, and the regulation of cell signaling pathways.

With a 100µg size, this antibody provides ample supply for multiple experiments and is compatible with various sample types, including cell lysates and tissue sections. Whether investigating DDR1's role in cell adhesion, extracellular matrix interactions, or disease mechanisms, this antibody is a valuable resource for your research.

Product Name

DDR1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing(By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

IMMUNOGEN INFORMATION

Immunogen

discoidin domain receptor tyrosine kinase 1

Synonyms

CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

Observed MW

101 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q08345

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