anti- FOXO1 antibody

Delve into the role of Forkhead Box O1 (FOXO1) in various cellular processes with our Anti-FOXO1 Antibody, available in a 100µg vial. FOXO1 is a transcription factor involved in insulin signaling, cell cycle regulation, and more. This highly specific antibody empowers researchers to investigate FOXO1's functions, contributing to a deeper understanding of its impact on metabolism and related research.

Key Features:

• Exceptional Specificity: Our Anti-FOXO1 Antibody is rigorously tested to ensure it accurately targets FOXO1, minimizing the risk of cross-reactivity.
• Versatile Applications: Ideal for various experimental techniques, including immunohistochemistry, Western blotting, and ChIP assays.
• Ample Quantity: With 100µg, you have a generous supply for multiple experiments.
• Top-Tier Quality: Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.
• Advance Your Research: Whether you're studying insulin signaling, cell cycle regulation, or related fields, our Anti-FOXO1 Antibody is your key to delving into FOXO1's role in cellular processes.
  
  

  Product Name

  FOXO1 antibody

  Size

  100µg

  Form

  liquid

  Purification

  Immunogen affinity purified

  Purity

  ≥95% as determined by SDS-PAGE

  Host

  Rabbit

  Clonality

  polyclonal

  Isotype

  IgG

  Storage

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

  BACKGROUND

  Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element(IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element(DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

  IMMUNOGEN INFORMATION

  Immunogen

  forkhead box O1

  Synonyms

  FKHR, FOXO1A

  Observed MW

  70-80 kDa

  APPLICATION

  Tested Application

  ELISA, WB

  Recommended Dilution

  WB: 1:200-1:2000

  UNIPROT INFORMATION

  UniProt ID

  Q12778

  IMAGES
  
  

  HeLa cells were subjected to SDS PAGE followed by western blot with FNab10255(FOXO1 Antibody) at dilution of 1:600