anti- APTX antibody

Embark on a journey into DNA repair and neurological research with our Anti-APTX Antibody, now available in a convenient 100µg size. Aprataxin (APTX) is a vital protein involved in DNA strand break repair and its mutations are linked to neurodegenerative disorders.

Our antibody is meticulously designed for exceptional specificity and sensitivity, ensuring accurate and reproducible results in a range of applications, from Western blotting to immunohistochemistry. Whether you're investigating APTX's role in ataxia or its functions in maintaining genomic integrity, our antibody is your trusted research companion.

The 100µg size offers cost-effective flexibility, accommodating both small-scale experiments and larger research initiatives. Its consistent quality and purity make it an ideal choice for researchers across diverse disciplines, from molecular biology to neurology.

Choose our Anti-APTX Antibody to propel your research forward and gain fresh insights into APTX-related processes. Rely on its performance and join the community of scientists who trust our products to drive scientific discovery.

Product Name

APTX antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

APTX, also named as Aprataxin, is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. APTX is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. APTX contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes.

IMMUNOGEN INFORMATION

Immunogen

aprataxin

Synonyms

AOA, AOA1, aprataxin, APTX, AXA1, EAOH, EOAHA, FHA HIT

Observed MW

40 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:20 - 1:200

UNIPROT INFORMATION

UniProt ID

Q7Z2E3

IMAGES