anti- ECD antibody

Investigate the intricate world of cellular regulation with our Anti-ECD Antibody, now available in a 100µg size. ECD, also known as Ecdysoneless Homolog, plays a crucial role in cellular processes, including cell cycle regulation.

This antibody is extensively validated for specificity, ensuring that your research on cell cycle control, cellular homeostasis, and cell division is supported by a reliable tool.

ECD's significance in cellular regulation and its role in cell cycle progression have made it a subject of significant research interest in the fields of cell biology and cancer research. Whether your research focuses on cell cycle checkpoints, tumor suppression, or cell proliferation, this antibody is an invaluable addition to your toolkit.

Product Name

ECD antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP(PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes(PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins(PubMed:19640839). The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex(PubMed:26711270). May play a role in regulation of pre-mRNA splicing(PubMed:24722212).

IMMUNOGEN INFORMATION

Immunogen

ecdysoneless homolog(Drosophila)

Synonyms

ECD, GCR2, HSGT1, Protein ecdysoneless homolog, Protein SGT1, SGT1, Suppressor of GCR2

Observed MW

70-100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O95905

IMAGES