anti- ATG12 antibody

Unveil the intricacies of the autophagy machinery with our Anti-ATG12 Antibody, now available in a 100µg size. ATG12, a critical protein in the autophagy process, is involved in the conjugation system essential for autophagosome formation and cargo engulfment.

Our meticulously developed monoclonal antibody ensures unparalleled specificity and sensitivity, making it the ideal choice for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. It provides the precision and reliability needed for accurate results in your autophagy research.

With 100µg at your disposal, you have an ample supply for multiple experiments, reducing interruptions and allowing you to maintain the momentum of your research.

Don't miss the opportunity to shed light on the multifaceted functions of ATG12 in autophagy. With our Anti-ATG12 Antibody, you can confidently delve into your research and uncover the secrets hidden within this essential autophagy-related protein.

Product Name

ATG12 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

IMMUNOGEN INFORMATION

Immunogen

ATG12 autophagy related 12 homolog

Synonyms

APG12, APG12L

Observed MW

48-50kd

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

O94817

IMAGES