anti- Amphiregulin antibody

Embark on a journey into the intricate world of growth factors and cell signaling with our specialized Anti-Amphiregulin Antibody, now available in a 100µg size. Amphiregulin (AREG) is a crucial epidermal growth factor receptor (EGFR) ligand, making it a valuable target for researchers investigating cell proliferation, tissue repair, and cancer biology.

Our meticulously crafted Anti-Amphiregulin Antibody offers exceptional specificity and sensitivity in various research applications, from immunohistochemistry to cell culture experiments. It has undergone rigorous validation to ensure consistent and reproducible results, minimizing experimental variability and optimizing resource utilization.

With 100µg of antibody, this product provides ample material for multiple experiments, striking a balance between cost-effectiveness and practicality. Engineered for user-friendliness, it accommodates researchers of all experience levels, enhancing the precision and reliability of experiments across various laboratory techniques.

Contribute to a deeper understanding of growth factor signaling, tissue regeneration, and cancer progression with confidence, supported by our high-quality Anti-Amphiregulin Antibody. Drive advancements in cell biology research and be part of groundbreaking discoveries in cell signaling pathways.

Product Name

Amphiregulin antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Amphiregulin(AREG) is one of the ligands of the epidermal growth factor receptor(EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms(PMID: 9642297).

IMMUNOGEN INFORMATION

Immunogen

amphiregulin

Synonyms

Amphiregulin, AR, AREG, AREGB, CRDGF, SDGF

Observed MW

43-50 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P15514

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