anti- androgen receptor antibody

Uncover the intricacies of hormone signaling and androgen receptor function with our Anti-Androgen Receptor Antibody, now available in a 100µg size. The androgen receptor plays a pivotal role in mediating the effects of androgens, making it a central target for researchers investigating hormone-related diseases and therapies.

Our Anti-Androgen Receptor Antibody is meticulously designed to provide exceptional specificity and sensitivity, making it suitable for various research applications, from immunohistochemistry to ChIP assays. Rigorous validation ensures consistent and reproducible results, effectively reducing experimental variability and optimizing resource utilization.

With 100µg of high-quality antibody, this product offers ample material for multiple experiments, striking a balance between cost-effectiveness and practicality. Engineered for user-friendliness, it accommodates researchers of all experience levels, enhancing the accuracy and dependability of experiments across various laboratory techniques.

Contribute to a deeper understanding of hormone signaling, androgen receptor biology, and related diseases with confidence, supported by our high-quality Anti-Androgen Receptor Antibody. Drive advancements in endocrinology research and be part of groundbreaking discoveries in hormone regulation.

Product Name

androgen receptor antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.

IMMUNOGEN INFORMATION

Immunogen

androgen receptor

Synonyms

AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM

Observed MW

45 kDa, 75-80 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:500-1:200

UNIPROT INFORMATION

UniProt ID

P10275

IMAGES