anti- AGER antibody

Unveiling our groundbreaking Anti-AGER Antibody, meticulously tailored to meet the exacting standards of scientific exploration. Available in a convenient 100µg size, this antibody is a game-changer in the field of immunology and molecular biology.

The Anti-AGER Antibody is your indispensable partner in deciphering the mysteries of AGER (Advanced Glycation End-Product Receptor). Engineered with exceptional specificity and sensitivity, it's the ideal choice for a broad spectrum of applications, spanning from Western blotting to immunohistochemistry and more.

What sets our Anti-AGER Antibody apart is its unparalleled performance, rigorously validated to ensure dependable and reproducible outcomes. By reducing experimental variability, it streamlines your research, saving you precious time and valuable resources.

Our 100µg size strikes the perfect balance between cost-efficiency and utility, providing an ample supply of antibody for multiple experiments while minimizing wastage. We're committed to sustainability and efficiency, contributing to your research endeavors in a responsible manner.

Crafted with user-friendliness in mind, the Anti-AGER Antibody suits researchers of all levels, from novices to seasoned experts. Its compatibility with various techniques ensures a seamless integration into your experimental protocols.

Empower your research with the assurance of utilizing a high-quality, meticulously engineered Anti-AGER Antibody. Elevate your scientific journey and contribute to pioneering breakthroughs in immunology and molecular biology. Rely on our dedication to innovation and excellence as you explore the frontiers of science with the Anti-AGER Antibody by your side.

Product Name

AGER antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

IMMUNOGEN INFORMATION

Immunogen

advanced glycosylation end product-specific receptor

Synonyms

AGER, RAGE

Observed MW

40-55 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15109

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