anti- CXCR4 antibody

Our Anti-CXCR4 Antibody, available in a 100µg size, is an indispensable tool for researchers studying CXCR4, a chemokine receptor with pivotal roles in immune cell migration, hematopoiesis, and cancer metastasis.

CXCR4, also known as C-X-C chemokine receptor type 4, is a critical player in various physiological and pathological processes, making it a central focus of research in diverse fields. With our antibody, you can confidently investigate the functions and interactions of CXCR4, gaining insights into its significance in cellular biology.

We have rigorously validated the specificity and sensitivity of this antibody to ensure accurate and reproducible results in your experiments. Its compact size allows for versatility in applications, whether you're conducting flow cytometry, immunohistochemistry, or in vivo studies. Trust in the quality of our Anti-CXCR4 Antibody to advance your scientific investigations and contribute to a deeper understanding of chemokine receptor signaling.

Product Name

CXCR4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609). CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649).

IMMUNOGEN INFORMATION

Immunogen

chemokine (C-X-C motif) receptor 4

Synonyms

CD184, CXC R4, CXCR 4, CXCR4, CXCR4B, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, LESTR, SDF 1 receptor, WHIM

Observed MW

40 kDa, 55 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P61073

IMAGES